Clinical Manifestations, Laboratory Findings, and Treatment Outcomes of SARS Patients
Identifieur interne : 005422 ( Main/Exploration ); précédent : 005421; suivant : 005423Clinical Manifestations, Laboratory Findings, and Treatment Outcomes of SARS Patients
Auteurs : Jann-Tay Wang [Taïwan] ; Wang-Huei Sheng [Taïwan] ; Chi-Tai Fang [Taïwan] ; Yee-Chun Chen [Taïwan] ; Jiun-Ling Wang [Taïwan] ; Chong-Jen Yu [Taïwan] ; Shan-Chwen Chang [Taïwan] ; Pan-Chyr Yang [Taïwan]Source :
- Emerging Infectious Diseases [ 1080-6040 ] ; 2004.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Femelle, Flambées de maladies, Hospitalisation, Humains, Maladies transmissibles émergentes (), Maladies transmissibles émergentes (mortalité), Maladies transmissibles émergentes (physiopathologie), Mâle, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (mortalité), Syndrome respiratoire aigu sévère (physiopathologie), Taïwan, Techniques de laboratoire clinique, Virus du SRAS, Études prospectives.
- MESH :
- mortalité : Maladies transmissibles émergentes, Syndrome respiratoire aigu sévère.
- physiopathologie : Maladies transmissibles émergentes, Syndrome respiratoire aigu sévère.
- Adulte, Adulte d'âge moyen, Femelle, Flambées de maladies, Hospitalisation, Humains, Maladies transmissibles émergentes, Mâle, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Syndrome respiratoire aigu sévère, Taïwan, Techniques de laboratoire clinique, Virus du SRAS, Études prospectives.
- Wicri :
- geographic : Taïwan.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Clinical Laboratory Techniques, Communicable Diseases, Emerging (mortality), Communicable Diseases, Emerging (physiopathology), Communicable Diseases, Emerging (therapy), Disease Outbreaks, Female, Hospitalization, Humans, Male, Middle Aged, Prospective Studies, SARS Virus, Severe Acute Respiratory Syndrome (mortality), Severe Acute Respiratory Syndrome (physiopathology), Severe Acute Respiratory Syndrome (therapy), Taiwan, Treatment Outcome.
- MESH :
- geographic : Taiwan.
- mortality : Communicable Diseases, Emerging, Severe Acute Respiratory Syndrome.
- physiopathology : Communicable Diseases, Emerging, Severe Acute Respiratory Syndrome.
- therapy : Communicable Diseases, Emerging, Severe Acute Respiratory Syndrome.
- Adult, Aged, Aged, 80 and over, Clinical Laboratory Techniques, Disease Outbreaks, Female, Hospitalization, Humans, Male, Middle Aged, Prospective Studies, SARS Virus, Treatment Outcome.
Abstract
Clinical and laboratory data on severe acute respiratory syndrome (SARS), particularly on the temporal progression of abnormal laboratory findings, are limited. We conducted a prospective study on the clinical, radiologic, and hematologic findings of SARS patients with pneumonia, who were admitted to National Taiwan University Hospital from March 8 to June 15, 2003. Fever was the most frequent initial symptom, followed by cough, myalgia, dyspnea, and diarrhea. Twenty-four patients had various underlying diseases. Most patients had elevated C-reactive protein (CRP) levels and lymphopenia. Other common abnormal laboratory findings included leukopenia, thrombocytopenia, and elevated levels of aminotransferase, lactate dehydrogenase, and creatine kinase. These clinical and laboratory findings were exacerbated in most patients during the second week of disease. The overall case-fatality rate was 19.7%. By multivariate analysis, underlying disease and initial CRP level were predictive of death.
Url:
DOI: 10.3201/eid1005.030640
PubMed: 15200814
PubMed Central: 3323212
Affiliations:
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Le document en format XML
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We conducted a prospective study on the clinical, radiologic, and hematologic findings of SARS patients with pneumonia, who were admitted to National Taiwan University Hospital from March 8 to June 15, 2003. Fever was the most frequent initial symptom, followed by cough, myalgia, dyspnea, and diarrhea. Twenty-four patients had various underlying diseases. Most patients had elevated C-reactive protein (CRP) levels and lymphopenia. Other common abnormal laboratory findings included leukopenia, thrombocytopenia, and elevated levels of aminotransferase, lactate dehydrogenase, and creatine kinase. These clinical and laboratory findings were exacerbated in most patients during the second week of disease. The overall case-fatality rate was 19.7%. By multivariate analysis, underlying disease and initial CRP level were predictive of death.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Wang, Jann Tay" sort="Wang, Jann Tay" uniqKey="Wang J" first="Jann-Tay" last="Wang">Jann-Tay Wang</name></noRegion><name sortKey="Chang, Shan Chwen" sort="Chang, Shan Chwen" uniqKey="Chang S" first="Shan-Chwen" last="Chang">Shan-Chwen Chang</name><name sortKey="Chen, Yee Chun" sort="Chen, Yee Chun" uniqKey="Chen Y" first="Yee-Chun" last="Chen">Yee-Chun Chen</name><name sortKey="Fang, Chi Tai" sort="Fang, Chi Tai" uniqKey="Fang C" first="Chi-Tai" last="Fang">Chi-Tai Fang</name><name sortKey="Sheng, Wang Huei" sort="Sheng, Wang Huei" uniqKey="Sheng W" first="Wang-Huei" last="Sheng">Wang-Huei Sheng</name><name sortKey="Wang, Jiun Ling" sort="Wang, Jiun Ling" uniqKey="Wang J" first="Jiun-Ling" last="Wang">Jiun-Ling Wang</name><name sortKey="Yang, Pan Chyr" sort="Yang, Pan Chyr" uniqKey="Yang P" first="Pan-Chyr" last="Yang">Pan-Chyr Yang</name><name sortKey="Yu, Chong Jen" sort="Yu, Chong Jen" uniqKey="Yu C" first="Chong-Jen" last="Yu">Chong-Jen Yu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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